Schnute, Mark E: search on Z-Library

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1

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

Mark E. Schnute, Patrick M. O’Brien, Joe Nahra, Mark Morris, W. Howard Roark, Cathleen E. Hanau, Peter G. Ruminski, Jeffrey A. Scholten, Theresa R. Fletcher, Bruce C. Hamper, Jeffery N. Carroll, Willi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 468 KB

english, 2010

2

Discovery of a Potent and Selective Sphingosine Kinase 1 Inhibitor through the Molecular Combination of Chemotype-Distinct Screening Hits

Schnute, Mark E., McReynolds, Matthew D., Carroll, Jeffrey, Chrencik, Jill, Highkin, Maureen K., Iyanar, Kaliapan, Jerome, Gina, Rains, John W., Saabye, Matthew, Scholten, Jeffrey A., Yates, Matthew,

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 904 KB

english, 2017

3

Cartilage degradation biomarkers predict efficacy of a novel, highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: Confirmation by multivariate analysis that modulation of type ii collagen and aggrecan degradation peptides parallels pathologic changes

Steven Settle, Lillian Vickery, Olga Nemirovskiy, Tom Vidmar, Alison Bendele, Dean Messing, Peter Ruminski, Mark Schnute, Teresa Sunyer

Journal:

Arthritis & Rheumatism

Year:

2010

Language:

english

File:

PDF, 284 KB

english, 2010

4

2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases

Mark E. Schnute, David J. Anderson, Roger J. Brideau, Fred L. Ciske, Sarah A. Collier, Michele M. Cudahy, MariJean Eggen, Michael J. Genin, Todd A. Hopkins, Thomas M. Judge, Euibong J. Kim, Mary L. Kn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 159 KB

english, 2007

5

Synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamides with broad-spectrum human herpesvirus polymerase inhibition

Mark E. Schnute, Roger J. Brideau, Sarah A. Collier, Michele M. Cudahy, Todd A. Hopkins, Mary L. Knechtel, Nancee L. Oien, Robert S. Sackett, Allen Scott, Mari L. Stephan, Michael W. Wathen, Janet L.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 254 KB

english, 2008

6

Structure analysis reveals the flexibility of the ADAMTS-5 active site

Huey-Sheng Shieh, Alfredo G. Tomasselli, Karl J. Mathis, Mark E. Schnute, Scott S. Woodard, Nicole Caspers, Jennifer M. Williams, James R. Kiefer, Grace Munie, Arthur Wittwer, Anne-Marie Malfait, Mick

Journal:

Protein Science

Year:

2011

Language:

english

File:

PDF, 598 KB

english, 2011

7

Gas-phase acidities of carboxylic acids and alcohols from collision-induced dissociation of dimer cluster ions

Susan T. Graul, Mark E. Schnute, Robert R. Squires

Journal:

International Journal of Mass Spectrometry and Ion Processes

Year:

1990

Language:

english

File:

PDF, 1.33 MB

english, 1990

8

Nitroalkene Inter [4 + 2]/Intra [3 + 2] Tandem Cycloadditions. 7. Application of (R)-(-)-2,2-Diphenylcyclopentanol as the Chiral Auxiliary

Denmark, Scott E., Schnute, Mark E., Marcin, Lawrence R., Thorarensen, Atli

Journal:

Journal of Organic Chemistry

Year:

1995

Language:

english

File:

PDF, 4.06 MB

english, 1995

9

Imidazo[1,5-a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis

Kyung-Hee Kim, Andreas Maderna, Mark E. Schnute, Martin Hegen, Shashi Mohan, Joy Miyashiro, Laura Lin, Evelyn Li, Sean Keegan, Jennifer Lussier, Christopher Wrocklage, Cheryl L. Nickerson-Nutter, Arth

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 984 KB

english, 2011

10

Protamine insulin: Its use in children

Alvah L. Newcomb, Mark W. Dick, Louise Schnute

Journal:

The Journal of Pediatrics

Year:

1937

Language:

english

File:

PDF, 509 KB

english, 1937

11

4-Oxo-4,7-dihydrothieno[2,3- b ]pyridines as Non-Nucleoside Inhibitors of Human Cytomegalovirus and Related Herpesvirus Polymerases

Schnute, Mark E., Cudahy, Michele M., Brideau, Roger J., Homa, Fred L., Hopkins, Todd A., Knechtel, Mary L., Oien, Nancee L., Pitts, Thomas W., Poorman, Roger A., Wathen, Michael W., Wieber, Janet L.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 177 KB

english, 2005

12

The First Formal Asymmetric Synthesis of Phorbol

Wender, Paul A., Rice, Kenneth D., Schnute, Mark E.

Journal:

Journal of the American Chemical Society

Year:

1997

Language:

english

File:

PDF, 83 KB

english, 1997

13

Tandem inter [4+2]/intra [3+2]nitroalkene cycloadditions. 5. Origin of the Lewis acid dependent reversal of stereoselectivity

Denmark, Scott E., Schnute, Mark E., Senanayake, C. B. W.

Journal:

Journal of Organic Chemistry

Year:

1993

Language:

english

File:

PDF, 3.15 MB

english, 1993

14

Encyclopedia of Reagents for Organic Synthesis || 3-Hydroxyisoborneol

Schnute, Mark E.

Year:

2001

Language:

english

File:

PDF, 154 KB

english, 2001

15

Encyclopedia of Reagents for Organic Synthesis || cis -3-[ N -(3,5-Dimethylphenyl)benzenesulfonamido]borneol

Schnute, Mark E.

Year:

2001

Language:

english

File:

PDF, 61 KB

english, 2001

16

Inhibition of Cytochrome P450 3A4 by a Pyrimidineimidazole: Evidence for Complex Heme Interactions

Hutzler, J. Matthew, Melton, Roger J., Rumsey, Jeanne M., Schnute, Mark E., Locuson, Charles W., Wienkers, Larry C.

Journal:

Chemical Research in Toxicology

Year:

2006

Language:

english

File:

PDF, 154 KB

english, 2006

17

Chemistry of Enoxysilacyclobutanes: Highly Selective Uncatalyzed Aldol Additions

Denmark, Scott E., Griedel, Brian D., Coe, Diane M., Schnute, Mark E.

Journal:

Journal of the American Chemical Society

Year:

1994

Language:

english

File:

PDF, 2.44 MB

english, 1994

18

Palladium-Promoted Intramolecular Addition of an Aryl Iodide to a Nitroalkene

Denmark, Scott E., Schnute, Mark E.

Journal:

Journal of Organic Chemistry

Year:

1995

Language:

english

File:

PDF, 885 KB

english, 1995

19

Tandem inter [4+2]/intra [3+2] cycloadditions. 3. The stereochemical influence of the Lewis acid

Denmark, Scott E., Schnute, Mark E.

Journal:

Journal of Organic Chemistry

Year:

1991

Language:

english

File:

PDF, 288 KB

english, 1991

20

Nitroalkene [4 + 2] Cycloadditions with 2-(Acyloxy)vinyl Ethers. Stereoselective Synthesis of 3-Hydroxy-4-substituted-pyrrolidines

Denmark, Scott E., Schnute, Mark E.

Journal:

Journal of Organic Chemistry

Year:

1994

Language:

english

File:

PDF, 4.11 MB

english, 1994

21

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

Lanning, Bryan R, Whitby, Landon R, Dix, Melissa M, Douhan, John, Gilbert, Adam M, Hett, Erik C, Johnson, Theodore O, Joslyn, Chris, Kath, John C, Niessen, Sherry, Roberts, Lee R, Schnute, Mark E, Wan

Journal:

Nature Chemical Biology

Year:

2014

Language:

english

File:

PDF, 2.08 MB

english, 2014

22

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1

Schnute, Mark E., McReynolds, Matthew D., Kasten, Tom, Yates, Matthew, Jerome, Gina, Rains, John W., Hall, Troii, Chrencik, Jill, Kraus, Michelle, Cronin, Ciaran N., Saabye, Matthew, Highkin, Maureen

Journal:

Biochemical Journal

Year:

2012

Language:

english

File:

PDF, 798 KB

english, 2012

23

Kinetic versus Thermodynamic Control in the Deprotonation of Unsymmetrical Ketones in the Gas Phase

Chyall, Leonard J., Brickhouse, Mark D., Schnute, Mark E., Squires, Robert R.

Journal:

Journal of the American Chemical Society

Year:

1994

Language:

english

File:

PDF, 1.19 MB

english, 1994

24

Discovery of 3-Cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide. A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 (RORC2) Inverse Agonist

Schnute, Mark E., Wennerstål, Mattias, Alley, Jennifer, Bengtsson, Martin, Blinn, James R., Bolten, Charles W., Braden, Timothy, Bonn, Tomas, Carlsson, Bo, Caspers, Nicole L., Chen, Ming Z., Choi, Chu

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.53 MB

english, 2018

25

Aminopyrazole Carboxamide Bruton’s Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning

Schnute, Mark E., Benoit, Stephen E., Buchler, Ingrid P., Caspers, Nicole, Grapperhaus, Margaret L., Han, Seungil, Hotchandani, Rajeev, Huang, Nelson, Hughes, Robert O., Juba, Brian M., Kim, Kyung-Hee

Journal:

ACS Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 271 KB

english, 2018

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